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Issue 11, 2008
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Fiber Bragg grating photoacoustic detector for liquid chromatography

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Abstract

Fiber Bragg Gratings (FBGs) are known to be sensitive acoustic transducers and have previously been used for the photoacoustic detection of small solid samples. Here, we demonstrate the use of an FBG as an on-line detector for liquid chromatography. The FBG was inserted into a silica capillary and the photoacoustic response from the effluent was generated by a 10 ns pulsed laser. The acoustic pulse was quantified by the FBG through a characteristic change in the reflection spectrum. Good repeatability and linear response were obtained over three orders of magnitude (R2 > 0.99), and the limit of detection of Coumarin 440 was determined to be 5 μM. The technique was successfully coupled to high performance liquid chromatography and applied to on-line analysis of a three-compound solution. Photoacoustic detection in liquid chromatography using FBGs is a label-free method, which can be applied to the detection of any chromogenic compound irrespective of its fluorogenic properties. It is a simple, inexpensive, and inherently micron-sized technique, insensitive to electromagnetic interference.

Graphical abstract: Fiber Bragg grating photoacoustic detector for liquid chromatography

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Publication details

The article was received on 11 Apr 2008, accepted on 23 Jun 2008 and first published on 11 Sep 2008


Article type: Paper
DOI: 10.1039/B806068A
Citation: Analyst, 2008,133, 1567-1572

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    Fiber Bragg grating photoacoustic detector for liquid chromatography

    Q. Yang, H. Loock, I. Kozin and D. Pedersen, Analyst, 2008, 133, 1567
    DOI: 10.1039/B806068A

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