Issue 10, 2008
From the journal:

Analyst

SERRS immunoassay for quantitative human CRP analysis†‡§

Fiona M. Campbell,a   Andrew Ingram,b   Paul Monaghan,c   Jon Cooper,c   Naveed Sattar,d   P. David Eckersall*a  and  Duncan Graham*b  

* Corresponding authors

a Division of Animal Production & Public Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
E-mail: P.d.eckersall@vet.gla.ac.uk
Fax: +44 141 330 2483 and +44 141 942 7215

b Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK
E-mail: Duncan.graham@strath.ac.uk

c Department of Electronics and Electrical Engineering Rankine Building, Oakfield Avenue University of Glasgow, Glasgow, UK

d Department of Vascular Biochemistry, Royal Infirmary, Glasgow, UK

Abstract

SERRS has been used for the first time for the measurement of C-reactive protein (CRP) in an immunoassay. CRP, a biological marker for the diagnosis of infection and inflammation, is quantified in an ELISA using conventional reagents, but the usual colorimetric detection step is replaced by SERRS detection, offering improved sensitivity and potential for multiplexing analysis.

Graphical abstract: SERRS immunoassay for quantitative human CRP analysis

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Article information

DOI
https://doi.org/10.1039/B808087A
Article type
Communication
Submitted
13 May 2008
Accepted
16 Jun 2008
First published
25 Jun 2008

Analyst, 2008,133, 1355-1357

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SERRS immunoassay for quantitative human CRP analysis

F. M. Campbell, A. Ingram, P. Monaghan, J. Cooper, N. Sattar, P. D. Eckersall and D. Graham, Analyst, 2008, 133, 1355 DOI: 10.1039/B808087A

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