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Issue 3, 2007
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Soft matters in cell adhesion: rigidity sensing on soft elastic substrates

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Abstract

This contribution highlights recent advances in our understanding of the relation between soft matter and biological systems. We first discuss the physical scales of living cells which follow from simple scaling arguments developed in soft matter physics. Then we discuss the way cells sense and react to extracellular stiffness as revealed by recent experiments with soft elastic substrates. Theoretical modelling allows addressing of the physical basis of the underlying mechanotransduction processes and its consequences for the organization of single cells and cell communities in soft environments. In the future, these efforts will also lead to an improved understanding of physiological and artificial tissue.

Graphical abstract: Soft matters in cell adhesion: rigidity sensing on soft elastic substrates

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Publication details

The article was received on 05 May 2006, accepted on 20 Jun 2006 and first published on 13 Jul 2006


Article type: Highlight
DOI: 10.1039/B606409D
Citation: Soft Matter, 2007,3, 263-266
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    Soft matters in cell adhesion: rigidity sensing on soft elastic substrates

    U. Schwarz, Soft Matter, 2007, 3, 263
    DOI: 10.1039/B606409D

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