Issue 1, 2007

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

Abstract

A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66–100%).

Graphical abstract: A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

Supplementary files

Article information

Article type
Communication
Submitted
21 Sep 2006
Accepted
25 Oct 2006
First published
06 Nov 2006

Org. Biomol. Chem., 2007,5, 61-64

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

A. Li, E. Ahmed, X. Chen, M. Cox, A. P. Crew, H. Dong, M. Jin, L. Ma, B. Panicker, K. W. Siu, A. G. Steinig, K. M. Stolz, P. A. R. Tavares, B. Volk, Q. Weng, D. Werner and M. J. Mulvihill, Org. Biomol. Chem., 2007, 5, 61 DOI: 10.1039/B613775J

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