Issue 21, 2007

Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor

Abstract

In the process of developing a series of novel, fluorinated biaryl ether NNRTIs, we fortuitously discovered derivative 20, which possesses excellent potency against both wild-type and clinically relevant mutations of the reverse transcriptase enzyme.

Graphical abstract: Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor

Supplementary files

Article information

Article type
Communication
Submitted
13 Sep 2007
Accepted
24 Sep 2007
First published
02 Oct 2007

Org. Biomol. Chem., 2007,5, 3431-3433

Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor

L. H. Jones, A. Randall, O. Barba and M. D. Selby, Org. Biomol. Chem., 2007, 5, 3431 DOI: 10.1039/B714091F

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