Issue 16, 2007
From the journal:

Organic & Biomolecular Chemistry

The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes†

Hélène Bertrand,a   David Monchaud,a   Anne De Cian,b   Régis Guillot,c   Jean-Louis Mergnyb  and  Marie-Paule Teulade-Fichou*a  

* Corresponding authors

a Institut Curie, Section Recherche, CNRS UMR176, Centre Universitaire Paris XI, Bât. 110, 91405 Orsay, France
E-mail: marie-paule.teulade-fichou@curie.fr
Fax: +33 1 6907 5381
Tel: +33 1 6986 3086

b INSERM, U565, CNRS UMR 5153, Muséum National d'Histoire Naturelle USM 503, 43 rue Cuvier, 75005 Paris, France

c Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS UMR8182, Université Paris XI, Bât. 420, 91405 Orsay, France

Abstract

A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity–selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.

Graphical abstract: The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

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Article information

DOI
https://doi.org/10.1039/B708635K
Article type
Communication
Submitted
07 Jun 2007
Accepted
25 Jun 2007
First published
05 Jul 2007

Org. Biomol. Chem., 2007,5, 2555-2559

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The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

H. Bertrand, D. Monchaud, A. De Cian, R. Guillot, J. Mergny and M. Teulade-Fichou, Org. Biomol. Chem., 2007, 5, 2555 DOI: 10.1039/B708635K

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