Issue 16, 2007
From the journal:

Organic & Biomolecular Chemistry

Sequence specific interstrand photocrosslinking for effective SNP typing

Takehiro Ami,a   Katsuya Ito,a   Yoshinaga Yoshimura*a  and  Kenzo Fujimoto*a  

* Corresponding authors

a School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
E-mail: kenzo@jaist.ac.jp
Fax: +81 761 51 1671
Tel: +81 761 51 1671

Abstract

We describe a simple and inexpensive SNP typing method by using sequence specific interstrand photocrosslinking via p-carbamoylvinyl phenol nucleosides. Interstrand photocrosslinking showed a high degree of single nucleotide specificity as high as 103-fold and more, and can be used in the diagnostic detection of DNA sequences.

Graphical abstract: Sequence specific interstrand photocrosslinking for effective SNP typing

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Article information

DOI
https://doi.org/10.1039/B708264A
Article type
Paper
Submitted
31 May 2007
Accepted
18 Jun 2007
First published
02 Jul 2007

Org. Biomol. Chem., 2007,5, 2583-2586

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Sequence specific interstrand photocrosslinking for effective SNP typing

T. Ami, K. Ito, Y. Yoshimura and K. Fujimoto, Org. Biomol. Chem., 2007, 5, 2583 DOI: 10.1039/B708264A

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