Issue 14, 2007

Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues

Abstract

The pyrrolidine-2,4-diones have been identified as a convenient starting point for the synthesis of peptide analogues. Herein we describe an optimized two-step reductive amination procedure, which provides a small library of pyrrolidinone-containing dipeptide analogues in high yield and excellent diastereoselectivity.

Graphical abstract: Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues

Supplementary files

Article information

Article type
Communication
Submitted
03 Apr 2007
Accepted
25 May 2007
First published
07 Jun 2007

Org. Biomol. Chem., 2007,5, 2207-2210

Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues

M. Hosseini, J. S. Grau, K. K. Sørensen, I. Søtofte, D. Tanner, A. Murray and J. E. Tønder, Org. Biomol. Chem., 2007, 5, 2207 DOI: 10.1039/B705093C

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