Issue 18, 2007
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed copper(i)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling†

Brajendra Kumar Singh,ab   Vaibhav Pravinchandra Mehta,a   Virinder Singh Parmarb  and  Erik Van der Eycken*a  

* Corresponding authors

a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, Heverlee/Leuven, Belgium
E-mail: Erik.VanderEycken@chem.kuleuven.be
Fax: +32 (0)16 327 990
Tel: +32 (0)16 327 406

b Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Abstract

The application of a palladium-catalyzed Cu(I)-mediated Liebeskind–Srogl protocol for the decoration of the 2(1H)-pyrazinone scaffold resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling.

Graphical abstract: Palladium-catalyzed copper(i)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling

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Article information

DOI
https://doi.org/10.1039/B704389A
Article type
Paper
Submitted
22 Mar 2007
Accepted
14 Jun 2007
First published
06 Aug 2007

Org. Biomol. Chem., 2007,5, 2962-2965

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Palladium-catalyzed copper(I)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling

B. K. Singh, V. P. Mehta, V. S. Parmar and E. Van der Eycken, Org. Biomol. Chem., 2007, 5, 2962 DOI: 10.1039/B704389A

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