Issue 11, 2007
From the journal:

Organic & Biomolecular Chemistry

Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol†

Michelle Pacholec,‡a   Jason K. Sello,§a   Christopher T. Walsh*a  and  Michael G. Thomas*b  

* Corresponding authors

a Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, USA
E-mail: christopher_walsh@hms.harvard.edu
Fax: +11 671 432-0438

b Department of Bacteriology, University of Wisconsin, Madison, WI, USA
E-mail: thomas@bact.wisc.edu
Fax: +11 608-262-9895

Abstract

Herein we report the first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol that provides new insights into the origins of the antibiotic.

Graphical abstract: Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

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Article information

DOI
https://doi.org/10.1039/B703356G
Article type
Communication
Submitted
05 Mar 2007
Accepted
16 Apr 2007
First published
26 Apr 2007

Org. Biomol. Chem., 2007,5, 1692-1694

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Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

M. Pacholec, J. K. Sello, C. T. Walsh and M. G. Thomas, Org. Biomol. Chem., 2007, 5, 1692 DOI: 10.1039/B703356G

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