Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+)

Raman Parkesh; Sridhar R. Vasudevan; Alexandra Berry; Antony Galione; James Dowden; Grant C. Churchill

doi:10.1039/B617344F

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Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP⁺)†

Raman Parkesh,*^a Sridhar R. Vasudevan,^a Alexandra Berry,^a Antony Galione,^a James Dowden^b and Grant C. Churchill^a

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* Corresponding authors

^a Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
E-mail: raman.parkesh@pharm.ox.ac.uk

^b School of Chemistry, University of Nottingham, University Park, Nottingham, UK

Abstract

A chemo-enzymatic synthesis of novel caged NAADP⁺ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP⁺ was demonstrated by its fast uncaging in intact sea-urchin eggs.

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Supplementary files

Synthetic detail and biological experiments PDF (352K)

Article information

DOI: https://doi.org/10.1039/B617344F
Article type: Communication
Submitted: 28 Nov 2006
Accepted: 28 Nov 2006
First published: 11 Dec 2006

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Org. Biomol. Chem., 2007,5, 441-443

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Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP⁺)

R. Parkesh, S. R. Vasudevan, A. Berry, A. Galione, J. Dowden and G. C. Churchill, Org. Biomol. Chem., 2007, 5, 441 DOI: 10.1039/B617344F

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Organic & Biomolecular Chemistry