Issue 4, 2007
From the journal:

Organic & Biomolecular Chemistry

An enantioselective Brønsted acid catalyzed enamine Mannich reaction†

A. Louise Tillmana  and  Darren J. Dixon*b  

* Corresponding authors

a University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, UK

b School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK
E-mail: darren.dixon@manchester.ac.uk
Fax: +44 (0) 161 275 4939

Abstract

An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H8-BINOL 11a has been identified as the optimal catalyst, to afford versatile β-amino aryl ketones in good yield and enantiomeric excess.

Graphical abstract: An enantioselective Brønsted acid catalyzed enamine Mannich reaction

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B616143J
Article type
Communication
Submitted
06 Nov 2006
Accepted
11 Dec 2006
First published
22 Dec 2006

Org. Biomol. Chem., 2007,5, 606-609

Permissions

Request permissions

An enantioselective Brønsted acid catalyzed enamine Mannich reaction

A. L. Tillman and D. J. Dixon, Org. Biomol. Chem., 2007, 5, 606 DOI: 10.1039/B616143J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements