Issue 2, 2007
From the journal:

Organic & Biomolecular Chemistry

An efficient and chemoselective synthesis of N-substituted 2-aminopyridines via a microwave-assisted multicomponent reaction†

Shujiang Tu,*a   Bo Jiang,a   Yan Zhang,a   Runhong Jia,a   Junyong Zhang,a   Changsheng Yaoa  and  Feng Shia  

* Corresponding authors

a Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant Xuzhou, Jiangsu, P. R. China
E-mail: laotu@xznu.edu.cn
Fax: +86(516) 83403164
Tel: +86(516) 83500349

Abstract

A facile and selective synthesis of N-substituted 2-aminopyridines is accomplished via microwave-assisted multi-component reactions controlled by the basicity of amine and the nature of solvent. In addition, a possible mechanism accounting for the reaction was proposed.

Graphical abstract: An efficient and chemoselective synthesis of N-substituted 2-aminopyridines via a microwave-assisted multicomponent reaction

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Article information

DOI
https://doi.org/10.1039/B614747J
Article type
Paper
Submitted
10 Oct 2006
Accepted
30 Oct 2006
First published
04 Dec 2006

Org. Biomol. Chem., 2007,5, 355-359

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An efficient and chemoselective synthesis of N-substituted 2-aminopyridines via a microwave-assisted multicomponent reaction

S. Tu, B. Jiang, Y. Zhang, R. Jia, J. Zhang, C. Yao and F. Shi, Org. Biomol. Chem., 2007, 5, 355 DOI: 10.1039/B614747J

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