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Issue 2, 2007
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Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

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Abstract

3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.

Graphical abstract: Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

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Publication details

The article was received on 26 Sep 2006, accepted on 02 Nov 2006 and first published on 11 Dec 2006


Article type: Paper
DOI: 10.1039/B613937J
Citation: Org. Biomol. Chem., 2007,5, 318-323

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    Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

    R. M. Haak, C. Tarabiono, D. B. Janssen, A. J. Minnaard, J. G. de Vries and B. L. Feringa, Org. Biomol. Chem., 2007, 5, 318
    DOI: 10.1039/B613937J

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