Solid phase synthesis of a prototype of a new class of biomimetic receptors for anionic carbohydrates

Abstract

A solid phase synthesis for a new biomimetic receptor 1 was developed. First binding studies show that 1 binds anionic carbohydrates such as glucose-1-phosphate and cAMP with association constants in the lower millimolar range in 20% buffered water in DMSO using both polar and apolar interactions.