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Issue 5, 2007
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Elucidating biosynthetic pathways for vitamins and cofactors

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Abstract

Covering: up to 2007

The elucidation of the pathways to the water-soluble vitamins and cofactors has provided many biochemical and chemical challenges. This is a reflection both of their complex chemical nature, and the fact that they are often made in small amounts, making detection of the enzyme activities and intermediates difficult. Here we present an orthogonal review of how these challenges have been overcome using a combination of methods, which are often ingenious. We make particular reference to some recent developments in the study of biotin, pantothenate, folate, pyridoxol, cobalamin, thiamine, riboflavin and molybdopterin biosynthesis.

Graphical abstract: Elucidating biosynthetic pathways for vitamins and cofactors

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Publication details

The article was received on 10 Aug 2007 and first published on 12 Sep 2007


Article type: Review Article
DOI: 10.1039/B703105J
Citation: Nat. Prod. Rep., 2007,24, 988-1008

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    Elucidating biosynthetic pathways for vitamins and cofactors

    M. E. Webb, A. Marquet, R. R. Mendel, F. Rébeillé and A. G. Smith, Nat. Prod. Rep., 2007, 24, 988
    DOI: 10.1039/B703105J

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