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Issue 2, 2007
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Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

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Abstract

A strategy based on the use of a tetradentate ligand containing two linked 8-hydroxyquinolines allowed a significant increase in the ability to protect against β-amyloid peptide precipitation in the presence of Cu(II), Zn(II) and Fe(III) when compared to clioquinol, a 8-hydroxyquinoline derivative active in vivo.

Graphical abstract: Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

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Publication details

The article was received on 06 Nov 2006, accepted on 19 Dec 2006 and first published on 09 Jan 2007


Article type: Letter
DOI: 10.1039/B616085A
Citation: New J. Chem., 2007,31, 193-195
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    Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

    C. Deraeve, M. Pitié, H. Mazarguil and B. Meunier, New J. Chem., 2007, 31, 193
    DOI: 10.1039/B616085A

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