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Issue 7, 2007
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Combinatorial variation of branching length and multivalency in a large (390 625 member) glycopeptide dendrimer library: ligands for fucose-specific lectins

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Abstract

A new approach to dendrimer property tuning is demonstrated by combinatorial variation of dendrimer branch length and multivalency level, using a large (390 625-member) self-encoded glycopeptide dendrimer library. Ligands for the fucose lectins of Ulex europaeus were identified by screening a combinatorial library of dendrimers with variable arm length (0–4 amino acids) and multivalency (2–5 end groups). The ligands identified by this approach also bind to the fucose lectin LecB (PA-IIL) of Pseudomonas aeruginosa, and might provide a possible starting point to develop anti-infective agents against this antibiotic resistant pathogen which causes lethal respiratory tract infections in cystic fibrosis patients.

Graphical abstract: Combinatorial variation of branching length and multivalency in a large (390 625 member) glycopeptide dendrimer library: ligands for fucose-specific lectins

  • This article is part of the themed collection: Dendrimers
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Supplementary files

Article information


Submitted
02 Nov 2006
Accepted
14 Feb 2007
First published
12 Mar 2007

New J. Chem., 2007,31, 1291-1299
Article type
Paper

Combinatorial variation of branching length and multivalency in a large (390 625 member) glycopeptide dendrimer library: ligands for fucose-specific lectins

E. M. V. Johansson, E. Kolomiets, F. Rosenau, K. Jaeger, T. Darbre and J. Reymond, New J. Chem., 2007, 31, 1291
DOI: 10.1039/B616051B

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