Jump to main content
Jump to site search

Issue 7, 2007
Previous Article Next Article

Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa

Author affiliations

Abstract

Homo- and hetero-bifunctional glycodendrimers ending with up to 16 fucoside and/or galactoside residues were synthesized in good yields using a convergent approach. The biologically active surface carbohydrate moieties were assembled in a single and efficient step using “click chemistry”. The relative binding and cross-linking abilities of these glycodendrimers were evaluated by turbidimetric analyses using both PA-IL and PA-IIL lectins from Pseudomonas aeruginosa. Insoluble complexes were rapidly observed from the first and second generations as well as from the mixed glycodendrimer 32. This hetero-bifunctional glycodendrimer was also evaluated with PA-IL alone and showed potent cross-linking properties. These novel heterobifunctional glycodendrimers may therefore constitute strong antiadhesin properties.

Graphical abstract: Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa

  • This article is part of the themed collection: Dendrimers
Back to tab navigation

Article information


Submitted
26 Jan 2007
Accepted
07 Mar 2007
First published
21 Mar 2007

New J. Chem., 2007,31, 1321-1331
Article type
Paper

Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to Pa-IL and PA-IIL lectins from Pseudomonas aeruginosa

I. Deguise, D. Lagnoux and R. Roy, New J. Chem., 2007, 31, 1321 DOI: 10.1039/B701237C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements