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Issue 7, 2007
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Applications of and alternatives to π-electron-deficient azine organometallics in metal catalyzed cross-coupling reactions

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Abstract

While the use of π-deficient azine halides in palladium catalyzed cross-coupling reactions is common, the use of π-electron deficient azine organometallics has been less intensively examined. In recent years, important advances have been made that are beginning to address this deficiency and need. The purpose of this tutorial review is to highlight and discuss the innovations that facilitate the synthesis of azine-containing biaryls with a focus on the pyridine structural motif. Given the number of important compounds which exhibit azine-heterobiaryls and the wide use of cross-coupling methods in their synthesis, this review should be of interest among synthetic organic chemists and organometallic chemists alike.

Graphical abstract: Applications of and alternatives to π-electron-deficient azine organometallics in metal catalyzed cross-coupling reactions

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Publication details

The article was received on 06 Nov 2006 and first published on 02 Mar 2007


Article type: Tutorial Review
DOI: 10.1039/B616082D
Citation: Chem. Soc. Rev., 2007,36, 1058-1068
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    Applications of and alternatives to π-electron-deficient azine organometallics in metal catalyzed cross-coupling reactions

    L. Campeau and K. Fagnou, Chem. Soc. Rev., 2007, 36, 1058
    DOI: 10.1039/B616082D

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