Stable polymorphs: difficult to make and difficult to predict
Abstract
Because α-glycine grows 500 times faster than γ-glycine, the small thermodynamic preference for γ-glycine is difficult to predict, detect and exploit.
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* Corresponding authors
a
Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore
E-mail:
ann_chow@ices.a-star.edu.sg
Fax: +65 6316 6183
Tel: +65 6796 3843
b
AstraZeneca, Silk Road Business Park, Charter Way, Macclesfield, Cheshire, UK
E-mail:
simon.black@astrazeneca.com
Fax: +44 1625 500780
Tel: +44 1625 514948
c
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore
E-mail:
Reginald_tan@ices.a-star.edu.sg
Fax: +65 6779 1936
Tel: +65 6516 6360
Because α-glycine grows 500 times faster than γ-glycine, the small thermodynamic preference for γ-glycine is difficult to predict, detect and exploit.
J. W. Chew, S. N. Black, P. S. Chow, R. B. H. Tan and K. J. Carpenter, CrystEngComm, 2007, 9, 128 DOI: 10.1039/B617321G
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