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Issue 44, 2007
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Metallo-intercalators and metallo-insertors

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Abstract

Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest. In particular, the study of transition metal complexes that bind DNA with specificity has been a burgeoning field. This growth has been due in large part to the useful properties of metal complexes, which possess a wide array of photophysical attributes and allow for the modular assembly of an ensemble of recognition elements. Here we review recent experiments in our laboratory aimed at the design and study of octahedral metal complexes that bind DNA non-covalently and target reactions to specific sites. Emphasis is placed both on the variety of methods employed to confer site-specificity and upon the many applications for these complexes. Particular attention is given to the family of complexes recently designed that target single base mismatches in duplex DNA through metallo-insertion.

Graphical abstract: Metallo-intercalators and metallo-insertors

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Article information


Submitted
17 Jul 2007
Accepted
31 Aug 2007
First published
20 Sep 2007

Chem. Commun., 2007, 4565-4579
Article type
Feature Article

Metallo-intercalators and metallo-insertors

B. M. Zeglis, V. C. Pierre and J. K. Barton, Chem. Commun., 2007, 4565
DOI: 10.1039/B710949K

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