Issue 35, 2007
From the journal:

Chemical Communications

A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A†

Kevin R. Bailey,a   Andrew J. Ellis,a   Renate Reiss,a   Timothy J. Snape*a  and  Nicholas J. Turner*a  

* Corresponding authors

a School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, UK
E-mail: tim.snape@manchester.ac.uk; nicholas.turner@manchester.ac.uk
Fax: +44 (0)161 275 1311
Tel: +44 (0)161 306 5100

Abstract

A template-based mnemonic has been developed for the enzyme monoamine oxidase from Aspergillus niger and has been used to successfully identify the alkaloid (±)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% e.e.

Graphical abstract: A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

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Article information

DOI
https://doi.org/10.1039/B710456A
Article type
Communication
Submitted
10 Jul 2007
Accepted
31 Jul 2007
First published
08 Aug 2007

Chem. Commun., 2007, 3640-3642

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A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

K. R. Bailey, A. J. Ellis, R. Reiss, T. J. Snape and N. J. Turner, Chem. Commun., 2007, 3640 DOI: 10.1039/B710456A

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