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Issue 27, 2007
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A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

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Abstract

We show that the use of multiple photochemistries is necessary to ensure diverse immobilisation of small molecules for binding of polypeptides using phage display and antibody libraries.

Graphical abstract: A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

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Publication details

The article was received on 21 Mar 2007, accepted on 21 May 2007 and first published on 12 Jun 2007


Article type: Communication
DOI: 10.1039/B704271J
Citation: Chem. Commun., 2007,0, 2808-2810

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    A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

    S. J. Dilly, M. J. Bell, A. J. Clark, A. Marsh, R. M. Napier, M. J. Sergeant, A. J. Thompson and P. C. Taylor, Chem. Commun., 2007, 0, 2808
    DOI: 10.1039/B704271J

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