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Issue 25, 2007
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Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

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Abstract

N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.

Graphical abstract: Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

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Supplementary files

Article information


Submitted
19 Feb 2007
Accepted
08 May 2007
First published
29 May 2007

Chem. Commun., 2007, 2581-2583
Article type
Communication

Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

N. McMillan, L. V. Smith, J. M. de la Fuente, A. D. C. Parenty, N. Gadegaard, A. R. Pitt, K. Thomson, C. MacKenzie, S. M. Kelly and L. Cronin, Chem. Commun., 2007, 2581
DOI: 10.1039/B702575K

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