Issue 43, 2007
From the journal:

Chemical Communications

Wash-free in-situ self-desalting and peptide enrichment by block copolymer analyzed with MALDI-TOFMS†

Ying Zhang,a   Jianhua Fang,b   Yongbo Kuang,b   Xiaoxia Guo,b   Haojie Lu*a  and  Pengyuan Yang*a  

* Corresponding authors

a Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China
E-mail: pyyang@fudan.edu.cn; luhaojie@fudan.edu.cn
Fax: (+86) 21-5423-7961 (P. Yang); (+86) 21-5423-7416 (H. Lu)

b School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

Abstract

A novel technique of simultaneous peptide enrichment and wash-free in-situ self-desalting for MALDI analysis is reported, where a newly synthesized block copolymer with a microphase-separated configuration is applied to embed salts with its hydrophilic domain of poly(ethylene oxide) and concentrate peptides with its hydrophobic domain of polysulfone.

Graphical abstract: Wash-free in-situ self-desalting and peptide enrichment by block copolymer analyzed with MALDI-TOFMS

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Article information

DOI
https://doi.org/10.1039/B710741B
Article type
Communication
Submitted
13 Jul 2007
Accepted
16 Aug 2007
First published
28 Aug 2007

Chem. Commun., 2007, 4468-4470

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Wash-free in-situ self-desalting and peptide enrichment by block copolymer analyzed with MALDI-TOFMS

Y. Zhang, J. Fang, Y. Kuang, X. Guo, H. Lu and P. Yang, Chem. Commun., 2007, 4468 DOI: 10.1039/B710741B

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