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Issue 41, 2007
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Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

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Abstract

A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

Graphical abstract: Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

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Publication details

The article was received on 13 Jun 2007, accepted on 27 Jul 2007 and first published on 10 Aug 2007


Article type: Communication
DOI: 10.1039/B708947C
Chem. Commun., 2007, 4260-4262

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    Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

    A. Suzuki, K. Tsumura, T. Tsuzuki, S. Matsumura and K. Toshima, Chem. Commun., 2007, 4260
    DOI: 10.1039/B708947C

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