Issue 28, 2007

A chemo- and regio-selective three-component dihydropyrimidinone synthesis

Abstract

A selective three-component coupling, involving co-condensation of aldehyde pairs with substituted ureas under Lewis acid catalysis, provides rapid access to highly functionalised dihydropyrimidinones; sulfamides react analogously.

Graphical abstract: A chemo- and regio-selective three-component dihydropyrimidinone synthesis

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2007
Accepted
04 Jun 2007
First published
19 Jun 2007

Chem. Commun., 2007, 2932-2934

A chemo- and regio-selective three-component dihydropyrimidinone synthesis

C. D. Bailey, C. E. Houlden, G. L. J. Bar, G. C. Lloyd-Jones and K. I. Booker-Milburn, Chem. Commun., 2007, 2932 DOI: 10.1039/B707361E

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