Issue 30, 2007
From the journal:

Chemical Communications

A trisulfide-linked glycoprotein†

Gonçalo J. L. Bernardes,a   Justin P. Marston,b   Andrei S. Batsanov,b   Judith A. K. Howardb  and  Benjamin G. Davis*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK
E-mail: Ben.Davis@chem.ox.ac.uk
Fax: +44 1865 275674
Tel: +44 1865 275652

b Department of Chemistry, University of Durham, South Road, Durham, UK

Abstract

The first member of a novel class of chemoselective reagents, glycosyl methanedithiosulfonates, has been synthesized, identified and employed in the first examples of chemical, site-selective construction of a trisulfide-modified protein with complete conversion.

Graphical abstract: A trisulfide-linked glycoprotein

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Article information

DOI
https://doi.org/10.1039/B706682A
Article type
Communication
Submitted
03 May 2007
Accepted
11 Jun 2007
First published
04 Jul 2007

Chem. Commun., 2007, 3145-3147

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A trisulfide-linked glycoprotein

G. J. L. Bernardes, J. P. Marston, A. S. Batsanov, J. A. K. Howard and B. G. Davis, Chem. Commun., 2007, 3145 DOI: 10.1039/B706682A

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