Issue 26, 2007
From the journal:

Chemical Communications

Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues†

Amanda Powell,a   Majid Al Nakeeb,a   Barrie Wilkinsonb  and  Jason Micklefield*a  

* Corresponding authors

a School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, UK
E-mail: Jason.micklefield@manchester.ac.uk
Tel: 306 4509

b Biotica, Chesterford Research Park, Little Chesterford, Essex, UK

Abstract

Precursor-directed biosynthesis of calcium dependent antibiotics (CDAs) with modified 3-trifluoromethyl and 3-ethyl glutamate residues was achieved by feeding synthetic glutamate analogues to a mutant strain of Streptomyces coelicolor impaired in the biosynthesis of the natural precursor (2S,3R)-3-methyl glutamic acid.

Graphical abstract: Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B706224A
Article type
Communication
Submitted
24 Apr 2007
Accepted
08 May 2007
First published
29 May 2007

Chem. Commun., 2007, 2683-2685

Permissions

Request permissions

Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues

A. Powell, M. Al Nakeeb, B. Wilkinson and J. Micklefield, Chem. Commun., 2007, 2683 DOI: 10.1039/B706224A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements