Issue 26, 2007
From the journal:

Chemical Communications

Optimized pH-responsive cyanine fluorochromes for detection of acidic environments†

Scott A. Hilderbrand*a  and  Ralph Weissledera  

* Corresponding authors

a Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
E-mail: Scott_Hilderbrand@hms.harvard.edu
Fax: +1 617 726 5708
Tel: +1 617 726 5788

Abstract

Modulation of pH-responsive cyanine dye pKa values via heteroatom substitution allows for design of fluorescent reporters that are tuned for potential imaging of biologically relevant acidic environments.

Graphical abstract: Optimized pH-responsive cyanine fluorochromes for detection of acidic environments

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Article information

DOI
https://doi.org/10.1039/B703764C
Article type
Communication
Submitted
13 Mar 2007
Accepted
02 Apr 2007
First published
20 Apr 2007

Chem. Commun., 2007, 2747-2749

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Optimized pH-responsive cyanine fluorochromes for detection of acidic environments

S. A. Hilderbrand and R. Weissleder, Chem. Commun., 2007, 2747 DOI: 10.1039/B703764C

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