Issue 28, 2007
From the journal:

Chemical Communications

Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented substrate scope†

Li Zhou,ac   Zhouyu Wang,abc   Siyu Weia  and  Jian Sun*a  

* Corresponding authors

a Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China
E-mail: sunjian@cib.ac.cn
Fax: +86-28-85222753
Tel: +86-28-85211220

b Department of Chemistry, Xihua University, Chengdu, China

c Graduate School of Chinese Academy of Sciences, Beijing, China

Abstract

L-Pipecolinic acid derived Lewis basic N-formamide 5e has been developed as a first highly effective catalyst for the asymmetric reduction of aromatic and aliphatic ketones as well as aromatic and aliphatic ketimines in good to high enantioselectivity.

Graphical abstract: Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented substrate scope

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Article information

DOI
https://doi.org/10.1039/B703307A
Article type
Communication
Submitted
05 Mar 2007
Accepted
24 Apr 2007
First published
09 May 2007

Chem. Commun., 2007, 2977-2979

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Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented substrate scope

L. Zhou, Z. Wang, S. Wei and J. Sun, Chem. Commun., 2007, 2977 DOI: 10.1039/B703307A

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