Issue 17, 2007
From the journal:

Chemical Communications

Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine†

Sadagopan Krishnan,a   Eli G. Hvastkovs,a   Besnik Bajrami,a   Ingela Jansson,b   John B. Schenkmanb  and  James F. Rusling*ab  

* Corresponding authors

a Department of Chemistry (U-60), 55 N. Eagleville Rd., University of Connecticut, USA
E-mail: james.rusling@uconn.edu

b Department of Pharmacology, University of Connecticut, USA

Abstract

We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.

Graphical abstract: Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine

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Article information

DOI
https://doi.org/10.1039/B703012F
Article type
Communication
Submitted
27 Feb 2007
Accepted
15 Mar 2007
First published
03 Apr 2007

Chem. Commun., 2007, 1713-1715

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Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine

S. Krishnan, E. G. Hvastkovs, B. Bajrami, I. Jansson, J. B. Schenkman and J. F. Rusling, Chem. Commun., 2007, 1713 DOI: 10.1039/B703012F

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