Chloride        anion transport and copper-mediated DNA cleavage by C-ring functionalized prodigiosenes

Rosa I. Sáez Díaz; Jasmine Regourd; Paul V. Santacroce; Jeffery T. Davis; David L. Jakeman; Alison Thompson

doi:10.1039/B701919J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Chlorideanion transport and copper-mediated DNA cleavage by C-ring functionalized prodigiosenes†

Rosa I. Sáez Díaz,^a Jasmine Regourd,^a Paul V. Santacroce,^b Jeffery T. Davis,^b David L. Jakeman^c and Alison Thompson*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
E-mail: Alison.Thompson@dal.ca
Fax: +1 902-494-1310
Tel: +1 902-494-6421

^b Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA

^c College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada

Abstract

A new class of prodigiosenes with stability-enhancing functionalities appended to the C-ring were found to transport chloride anions through liposomal membranes, as well as to induce copper-mediated DNA cleavage.

Download options Please wait...

Supplementary files

Experimental details, representative EC ₅₀ curve (for 8), and photographs of all agarose gels PDF (6148K)

Article information

DOI: https://doi.org/10.1039/B701919J
Article type: Communication
Submitted: 12 Feb 2007
Accepted: 29 Mar 2007
First published: 17 Apr 2007

Download Citation

Chem. Commun., 2007, 2701-2703

Permissions

Request permissions

Chloride anion transport and copper-mediated DNA cleavage by C-ring functionalized prodigiosenes

R. I. S. Díaz, J. Regourd, P. V. Santacroce, J. T. Davis, D. L. Jakeman and A. Thompson, Chem. Commun., 2007, 2701 DOI: 10.1039/B701919J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications