Issue 14, 2007
From the journal:

Chemical Communications

A reductase-mimicking thiourea organocatalyst incorporating a covalently bound NADH analogue: efficient 1,2-diketone reduction with in situ prosthetic group generation and recycling†

Barbara Procurantia  and  Stephen J. Connon*a  

* Corresponding authors

a Centre for Synthesis and Chemical Biology, School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland
E-mail: connons@tcd.ie
Fax: +353 1 6712826
Tel: +353 1 6081306

Abstract

A new class of bifunctional organocatalyst promotes the chemoselective reduction of diketone electrophiles at catalytic loadings in the presence of an inorganic co-reductant.

Graphical abstract: A reductase-mimicking thiourea organocatalyst incorporating a covalently bound NADH analogue: efficient 1,2-diketone reduction with in situ prosthetic group generation and recycling

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Article information

DOI
https://doi.org/10.1039/B618792G
Article type
Communication
Submitted
02 Jan 2007
Accepted
04 Jan 2007
First published
30 Jan 2007

Chem. Commun., 2007, 1421-1423

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A reductase-mimicking thiourea organocatalyst incorporating a covalently bound NADH analogue: efficient 1,2-diketone reduction with in situ prosthetic group generation and recycling

B. Procuranti and S. J. Connon, Chem. Commun., 2007, 1421 DOI: 10.1039/B618792G

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