Issue 25, 2007
From the journal:

Chemical Communications

Deacylation studies on furanose triesters using an immobilized lipase: Synthesis of a key precursor for bicyclonucleosides†

Ashok K. Prasad,*a   Neerja Kalra,ab   Yogesh Yadav,a   Rajesh Kumar,a   Sunil K. Sharma,a   Shamkant Patkar,c   Lene Lange,c   Jesper Wengel*b  and  Virinder S. Parmar*a  

* Corresponding authors

a Bioorganic Laboratory, Department of Chemistry, University of Delhi, India
E-mail: virparmar@gmail.com
Fax: +91 11 2766 7206
Tel: +91 11 2766 6555

b Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, Denmark

c Novozymes A/S, Denmark, Smormosevej 25, Denmark

Abstract

Lipozyme® TL IM immobilized on silica catalyses the deacylation of 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose to form 3,5-di-O-acyl-4-C-hydroxymethyl-1,2-O-(1-methylethylidene)-α-D-xylo-pentofuranose in a highly selective and efficient manner.

Graphical abstract: Deacylation studies on furanose triesters using an immobilized lipase: Synthesis of a key precursor for bicyclonucleosides

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Article information

DOI
https://doi.org/10.1039/B618426J
Article type
Communication
Submitted
18 Dec 2006
Accepted
20 Feb 2007
First published
27 Mar 2007

Chem. Commun., 2007, 2616-2617

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Deacylation studies on furanose triesters using an immobilized lipase: Synthesis of a key precursor for bicyclonucleosides

A. K. Prasad, N. Kalra, Y. Yadav, R. Kumar, S. K. Sharma, S. Patkar, L. Lange, J. Wengel and V. S. Parmar, Chem. Commun., 2007, 2616 DOI: 10.1039/B618426J

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