Issue 15, 2007
From the journal:

Chemical Communications

Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst

Tom S. C. Eve,a   Andrew Wellsb  and  Nicholas J. Turner*c  

* Corresponding authors

a School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK

b AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire, UK

c School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, UK
E-mail: nicholas.turner@manchester.ac.uk
Fax: +44 161 275 1311
Tel: +44 161 306 5173

Abstract

Enantioselective oxidation of racemic O-methyl-N-hydroxycyclohexylethylamine, using a variant of monoamine oxidase N (MAO-N) from Aspergillus niger, yields unreacted (R)-enantiomer (e.e. = 99%) together with the oxime exclusively in the (E)-configuration.

Graphical abstract: Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst

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Article information

DOI
https://doi.org/10.1039/B617537F
Article type
Communication
Submitted
01 Dec 2006
Accepted
17 Jan 2007
First published
05 Feb 2007

Chem. Commun., 2007, 1530-1531

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Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst

T. S. C. Eve, A. Wells and N. J. Turner, Chem. Commun., 2007, 1530 DOI: 10.1039/B617537F

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