Issue 2, 2007
From the journal:

Chemical Communications

A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer†

Felix Freire,a   Igor Cuesta,a   Francisco Corzana,b   Julia Revuelta,a   Carlos González,c   Milos Hricovini,d   Agatha Bastida,a   Jesús Jiménez-Barberoe  and  Juan Luis Asensio*a  

* Corresponding authors

a Instituto de Química Orgánica General (CSIC), c/Juan de la Cierva 3, Madrid, Spain
E-mail: iqoa110@iqog.csic.es
Fax: +34 91 5644853
Tel: +34 91 5622900

b Departamento de Química, Universidad de La Rioja, U.A.-C.S.I.C., Madre de Dios 51, 26006 Logroño, Spain

c Instituto de Química Física Rocasolano (CSIC), Serrano 119, 28006 Madrid, Spain

d Slovak academy of Science, Institute of Chemistry, Bratislava 84538, Slovakia

e Centro de investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain

Abstract

A complete characterisation of the protonation equilibrium that accompanies the molecular recognition of neomycin-B by a specific RNA receptor has been achieved by employing simple NMR measurements.

Graphical abstract: A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer

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Article information

DOI
https://doi.org/10.1039/B611597G
Article type
Communication
Submitted
10 Aug 2006
Accepted
27 Sep 2006
First published
23 Oct 2006

Chem. Commun., 2007, 174-176

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A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer

F. Freire, I. Cuesta, F. Corzana, J. Revuelta, C. González, M. Hricovini, A. Bastida, J. Jiménez-Barbero and J. L. Asensio, Chem. Commun., 2007, 174 DOI: 10.1039/B611597G

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