Issue 11, 2006
From the journal:

Photochemical & Photobiological Sciences

Synthesis of estradiol–pheophorbidea conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells

Naram El-Akra,a   Arielle Noirot,a   Jean-Charles Fayeb  and  Jean-Pierre Souchard*a  

* Corresponding authors

a Laboratoire des Interactions Moléculaires et Réactivités Chimiques et Photochimiques, Université Paul Sabatier, 118 Rte de Narbonne, Toulouse Cedex 9
E-mail: souchard@chimie.ups-tlse.fr
Fax: +33 (0)5 61 55 81 55
Tel: +33(0)5 61 55 77 43

b INSERM U563 Département Innovation Thérapeutique et Oncologie Moléculaire, Institut Claudius Regaud, 20 rue du Pont Saint-Pierre, Toulouse Cedex

Abstract

The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol–pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells.

Graphical abstract: Synthesis of estradiol–pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells

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Article information

DOI
https://doi.org/10.1039/B606117F
Article type
Communication
Submitted
03 May 2006
Accepted
13 Aug 2006
First published
09 Oct 2006

Photochem. Photobiol. Sci., 2006,5, 996-999

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Synthesis of estradiol–pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells

N. El-Akra, A. Noirot, J. Faye and J. Souchard, Photochem. Photobiol. Sci., 2006, 5, 996 DOI: 10.1039/B606117F

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