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Issue 12, 2006
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Lipid fluorination enables phase separation from fluid phospholipid bilayers

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Abstract

To probe the effect of lipid fluorination on the formation of lipid domains in phospholipid bilayers, several new fluorinated and non-fluorinated synthetic lipids were synthesised, and the extent of phase separation of these lipids from phospholipid bilayers of different compositions was determined. At membrane concentrations as low as 1% mol/mol, both fluorinated and non-fluorinated lipids were observed to phase separate from a gel-phase (solid ordered) phospholipid matrix, but bilayers in a liquid disordered state caused no phase separation; if the gel-phase samples were heated above the transition temperature, then phase separation was lost. We found incorporation of perfluoroalkyl groups into the lipid enhanced phase separation, to such an extent that phase separation was observed from cholesterol containing bilayers in the liquid ordered phase.

Graphical abstract: Lipid fluorination enables phase separation from fluid phospholipid bilayers

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Publication details

The article was received on 06 Mar 2006, accepted on 05 Apr 2006 and first published on 10 May 2006


Article type: Paper
DOI: 10.1039/B603373N
Citation: Org. Biomol. Chem., 2006,4, 2399-2407
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    Lipid fluorination enables phase separation from fluid phospholipid bilayers

    S. J. Webb, K. Greenaway, M. Bayati and L. Trembleau, Org. Biomol. Chem., 2006, 4, 2399
    DOI: 10.1039/B603373N

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