Issue 22, 2006
From the journal:

Organic & Biomolecular Chemistry

New C-3′ hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents

Marvin J. Miller,*a   Gaiying Zhao,a   Sergei Vakulenko,a   Scott Franzblaub  and  Ute Möllmannc  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, USA
E-mail: mmiller1@nd.edu
Fax: +1 574-631-6652

b College of Pharmacy Institute for Tuberculosis Research, M/C 964, Rm 412, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois, (USA)

c Leibniz-Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Beutenbergstrasse 11a, Jena, Germany

Abstract

Syntheses of a series of new C-3′ hydroxamate-substituted cephalosporin derivatives with potent antibacterial and media-dependent anti-TB activity are described.

Graphical abstract: New C-3′ hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents

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Article information

DOI
https://doi.org/10.1039/B612475E
Article type
Paper
Submitted
29 Aug 2006
Accepted
22 Sep 2006
First published
12 Oct 2006

Org. Biomol. Chem., 2006,4, 4178-4185

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New C-3′ hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents

M. J. Miller, G. Zhao, S. Vakulenko, S. Franzblau and U. Möllmann, Org. Biomol. Chem., 2006, 4, 4178 DOI: 10.1039/B612475E

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