Issue 24, 2006
From the journal:

Organic & Biomolecular Chemistry

Practical synthesis of chiral 9,9′-spirobixanthene-1,1′-diol

Weicheng Zhang,a   Shulin Wu,a   Zhaoguo Zhang,a   Hemant Yennawarb  and  Xumu Zhang*a  

* Corresponding authors

a 104 Chemistry Research Building, Department of Chemistry, the Pennsylvania State University, University Park, PA, USA
E-mail: xumu@chem.psu.edu
Fax: (+1) 814-865-3932

b The Department of Chemistry X-ray Crystallography Lab, the Pennsylvania State University, University Park, PA, USA

Abstract

A concise four-step synthesis of 9,9′-spirobixanthene-1,1′-diol is reported, featuring a practical preparation at large scale without the use of column chromatography purification. Co-crystallization with N-benzylcinchonidinium chloride and N-benzylquininium chloride rendered the optically pure product in both enantiomers.

Graphical abstract: Practical synthesis of chiral 9,9′-spirobixanthene-1,1′-diol

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Article information

DOI
https://doi.org/10.1039/B610879B
Article type
Paper
Submitted
31 Jul 2006
Accepted
25 Oct 2006
First published
09 Nov 2006

Org. Biomol. Chem., 2006,4, 4474-4477

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Practical synthesis of chiral 9,9′-spirobixanthene-1,1′-diol

W. Zhang, S. Wu, Z. Zhang, H. Yennawar and X. Zhang, Org. Biomol. Chem., 2006, 4, 4474 DOI: 10.1039/B610879B

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