Issue 20, 2006
From the journal:

Organic & Biomolecular Chemistry

Conformational analogues of Oxamflatin as histone deacetylase inhibitors

Anthony E. Dear,a   Hong B. Liu,a   Penelope A. Mayesb  and  Patrick Perlmutter*b  

* Corresponding authors

a Australian Centre for Blood Diseases, Department of Medicine, Monash University, 6th floor Barnet Tower, 89 Commercial Rd, Prahran, Australia

b School of Chemistry, Box 23, Monash University, Australia
E-mail: patrick.perlmutter@sci.monash.edu.au

Abstract

Conformational analogues of the hydroxamic acid Oxamflatin 1—compounds 3a, 3b and 4—have been synthesised to enable evaluation of the impact of varying the linking section on histone deacetylase inhibition. Preliminary testing indicates treatment of leukaemia cells with each of the analogues leads to significant inhibition of histone deacetylase and reduction in cell growth and proliferation.

Graphical abstract: Conformational analogues of Oxamflatin as histone deacetylase inhibitors

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Article information

DOI
https://doi.org/10.1039/B608213K
Article type
Paper
Submitted
09 Jun 2006
Accepted
18 Jul 2006
First published
31 Aug 2006

Org. Biomol. Chem., 2006,4, 3778-3784

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Conformational analogues of Oxamflatin as histone deacetylase inhibitors

A. E. Dear, H. B. Liu, P. A. Mayes and P. Perlmutter, Org. Biomol. Chem., 2006, 4, 3778 DOI: 10.1039/B608213K

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