Issue 19, 2006
From the journal:

Organic & Biomolecular Chemistry

Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis†

Raman Parkesh,ab   Wolfgang Gowin,c   T. Clive Leeb  and  Thorfinnur Gunnlaugsson*a  

* Corresponding authors

a School of Chemistry, Centre for Synthesis and Chemical Biology (CSCB), Trinity College Dublin, Dublin 2, Ireland
E-mail: gunnlaut@tcd.ie
Fax: 00 353 1 671 2826
Tel: 00 353 1 608 3459

b Department of Anatomy, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland

c Center of Muscle and Bone Research, Department of Radiology and Nuclear Medicine, Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany

Abstract

The design and synthesis of several novel X-ray contrast agents 1–3, developed for targeting bone structures, and in particularly microcracks in bones, using CT (Computer Tomography) detection is described. These contrast agents are based on the use of the well known triiodobenzene platform, which was conjugated into one or more phenyliminodiacetate moieties, which can be used to ‘lock’ onto bone matrices. Compounds 1–3 were all tested for their ability to visualise cracks in bone structures (bovine bones) using μ-CT imaging.

Graphical abstract: Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis

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Article information

DOI
https://doi.org/10.1039/B606976B
Article type
Paper
Submitted
16 May 2006
Accepted
07 Jul 2006
First published
15 Aug 2006

Org. Biomol. Chem., 2006,4, 3611-3617

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Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis

R. Parkesh, W. Gowin, T. C. Lee and T. Gunnlaugsson, Org. Biomol. Chem., 2006, 4, 3611 DOI: 10.1039/B606976B

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