Issue 17, 2006
From the journal:

Organic & Biomolecular Chemistry

Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

Yang Song,a   Tian Tian,a   Ping Wang,a   Hanping He,a   Wulue Liu,a   Xiang Zhou,*ab   Xiaoping Cao,d   Xiao-Lian Zhang*c  and  Xin Zhou*e  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan, P. R. of China
E-mail: xzhou@whu.edu.cn

b Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing, P. R. of China

c College of Medicine, Wuhan University, Hubei, Wuhan, P. R. of China

d National Applied Organic Chemistry, Lanzhou University, Gansu Lanzhou, P. R. of China

e Zhongnan Hospital, Wuhan University, Hubei, Wuhan, P. R. of China

Abstract

We report here that phenol derivatives with two and four quaternary ammoniums were synthesized and their abilities to bind and cross-link DNA were investigated. Thermal denaturizing studies indicated that derivatives possess similar DNA binding abilities and gel electrophoresis revealed that more charges (series B) and electronic donation substitute linkers (like –S–) dramatically increase the DNA cross-linking abilities.

Graphical abstract: Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B604552A
Article type
Paper
Submitted
29 Mar 2006
Accepted
07 Jul 2006
First published
01 Aug 2006

Org. Biomol. Chem., 2006,4, 3358-3366

Permissions

Request permissions

Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

Y. Song, T. Tian, P. Wang, H. He, W. Liu, X. Zhou, X. Cao, X. Zhang and X. Zhou, Org. Biomol. Chem., 2006, 4, 3358 DOI: 10.1039/B604552A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements