The synthesis of tethered ligand dimers for PPARγ–RXR protein heterodimers
Abstract
Heterodimeric compounds based on tethering the PPARγ agonist Rosiglitazone to the RXR ligand Targretin have been prepared.
* Corresponding authors
a Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, USA
b
Department of Chemistry, James Madison University, MSC 4501, Harrisonburg, Virginia, USA
E-mail:
mohlerdl@jmu.edu
Fax: 540-568-7938
Tel: 540-568-8803
Heterodimeric compounds based on tethering the PPARγ agonist Rosiglitazone to the RXR ligand Targretin have been prepared.
D. L. Mohler and G. Shen, Org. Biomol. Chem., 2006, 4, 2082 DOI: 10.1039/B600848H
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