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Issue 1, 2006
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Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

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Abstract

A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedländer condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.

Graphical abstract: Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

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Publication details

The article was received on 27 Sep 2005, accepted on 28 Oct 2005 and first published on 18 Nov 2005


Article type: Paper
DOI: 10.1039/B513721G
Citation: Org. Biomol. Chem., 2006,4, 104-110
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    Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

    C. Jia, Z. Zhang, S. Tu and G. Wang, Org. Biomol. Chem., 2006, 4, 104
    DOI: 10.1039/B513721G

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