Issue 9, 2006
From the journal:

Green Chemistry

Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO2

Helen R. Hobbs,a   Betti Kondor,a   Phil Stephenson,a   Roger A. Sheldon,b   Neil R. Thomasc  and  Martyn Poliakoff*a  

* Corresponding authors

a School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: martyn.poliakoff@nottingham.ac.uk
Fax: +44 115 9513058
Tel: +44 115 9513520

b Biocatalysis and Organic Chemistry, Department of Biotechnology, Delft University of Technology, Julianalaan 136, Delft, The Netherlands
E-mail: R.A.Sheldon@tnw.tudelft.nl
Tel: +31 15 2782675

c Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK
E-mail: neil.thomas@nottingham.ac.uk
Tel: +44 115 9513565

Abstract

We report the use of cross-linked enzyme aggregates (CLEAs®) to catalyse the kinetic resolution of tetralol and 1-phenylethanol in a continuous supercritical carbon dioxide (scCO2) system. We describe the performance of the CLEA from Candida antarctica lipase B (CALB) and compare this to the catalytic activity of Novozym 435 (CALB immobilised on a macroporous acrylic resin). In addition, we report a two-stage reaction with the kinetic resolution of 1-phenylethanol performed in series with the metal (Pd) catalysed hydrogenation of acetophenone. Reactions performed in series have a potential economic advantage as the second, and subsequent reactions do not require additional expenditure of energy for re-pressurization of solvent.

Graphical abstract: Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO2

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Article information

DOI
https://doi.org/10.1039/B604738F
Article type
Paper
Submitted
03 Apr 2006
Accepted
23 Jun 2006
First published
17 Jul 2006

Green Chem., 2006,8, 816-821

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Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO2

H. R. Hobbs, B. Kondor, P. Stephenson, R. A. Sheldon, N. R. Thomas and M. Poliakoff, Green Chem., 2006, 8, 816 DOI: 10.1039/B604738F

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