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Issue 6, 2006
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Absorption spectroscopy and binding constants for first-row transition metal complexes of a DOPA-containing peptide

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Abstract

A diverse array of biological systems incorporate 3,4-dihydroxyphenlyalanine (DOPA) into proteins and small molecules for cross-linking and material generation. Marine worm eggshells, sea squirt wound plugs, and marine mussel adhesives may all be formed by combining DOPA-containing molecules with high levels of metals. In order to provide model systems for characterizing these biomaterials, we carried out a study on metal binding to a DOPA-containing peptide. Ultraviolet-visible absorption spectra are presented for the AdopaTP peptide binding to Fe3+, V3+, VO2+, Mn3+, Ti4+, Cu2+, Co2+, and Ni2+ in mono, bis, and where applicable, tris coordination modes. Association constants were determined for selected metal ions binding to the peptide. In general, the spectroscopic and binding properties of this DOPA-containing peptide were found to be similar to those of catechol.

Graphical abstract: Absorption spectroscopy and binding constants for first-row transition metal complexes of a DOPA-containing peptide

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Publication details

The article was received on 06 Jul 2005, accepted on 04 Oct 2005 and first published on 27 Oct 2005


Article type: Paper
DOI: 10.1039/B509586G
Dalton Trans., 2006, 813-822

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    Absorption spectroscopy and binding constants for first-row transition metal complexes of a DOPA-containing peptide

    M. J. Sever and J. J. Wilker, Dalton Trans., 2006, 813
    DOI: 10.1039/B509586G

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