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Issue 16, 2006
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Cyanide ion cocatalysis in Ti(salen) catalysed asymmetric cyanohydrin carbonate synthesis

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Abstract

In the presence of potassium cyanide or the potassium cyanide/18-crown-6 complex as a cocatalyst, 1–2 mol% of titanium(salen) complex 1 catalyses the asymmetric addition of achiral cyanoformates to aldehydes, giving cyanohydrin carbonates with high enantiomeric excesses; and catalyses the diastereoselective addition of chiral cyanoformates derived from α-methylbenzyl alcohol to aldehydes, a reaction which exhibits double asymmetric induction.

Graphical abstract: Cyanide ion cocatalysis in Ti(salen) catalysed asymmetric cyanohydrin carbonate synthesis

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Publication details

The article was received on 14 Feb 2006, accepted on 06 Mar 2006 and first published on 17 Mar 2006


Article type: Communication
DOI: 10.1039/B602156E
Citation: Chem. Commun., 2006,0, 1775-1777
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    Cyanide ion cocatalysis in Ti(salen) catalysed asymmetric cyanohydrin carbonate synthesis

    Y. N. Belokon, E. Ishibashi, H. Nomura and M. North, Chem. Commun., 2006, 0, 1775
    DOI: 10.1039/B602156E

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